Software model checker blastomycosis

Blastomycosis is an infection caused by the fungus blastomyces. The presence of blastomyces dermatitidis may be indicated by a white or tan mold in moist soil and decaying wood, but may also be present without any distinguishing signs the fungus is found in acidic, moist soil in parts of northern ontario, manitoba. Blastomycosis is a rare fungal infection that most commonly affects the lungs. Laboratory diagnosis of blastomycosis sciencedirect. Blastomyces lives in the environment as a mold that produces fungal spores.

In north american blastomycosis, skin and lung lesions are most common. Farmers, construction workers, and others who work with soil appear to be at increased risk for blastomycosis. The software model checker blast welcome to software. Blastomycosis is endemic in regions of north america that border the. Symptoms of acute blastomycosis include an influenzalike illness with fever, cough, myalgia, arthralgia, and pleurisy. Explore the causes of blastomycosis and how it is spread. Blastomycosis mortality rates, united states, 19902010. Software model checking is the algorithmic analysis of programs to prove prop erties of their executions. Treatment of choice is itraconazole 200400 mg daily for 612 months, and severe pulmonary or disseminated blastomycosis is treated with iv amphotericin b followed by an oral azole. It is not a new condition and has been known for many years. Blastomycosis is a potentially fatal fungal infection endemic to parts of north america. Blast employs counterexampledriven automatic abstraction refinement to construct an abstract model that is then modelchecked for safety properties. Diagnosis is clinical, by chest xray, or both and is.

Blastomyces gilchristii is a more recently described species that causes similar illness. Acute blastomycosis can resolve spontaneously without treatment. The task addressed by blast is the need to check whether software satisfies the behavioral requirements of its associated interfaces. You may develop mild symptoms, but recover without ever knowing you had been infected. In this survey we trace some of these ideas that have combined to produce. Due to the nonspecific characteristics of the clinical disease it is important that the clinician consider a fungal etiology and request the ap propriate laboratory studies. Blastomycosis is found predominately in the central and southeast u. Blastomycosis is a systemic fungal disease, most commonly diagnosed in dogs and humans, but also reported in cats, 1 horses, 2 and other mammals. We used national multiplecauseofdeath data and census population estimates for 19902010 to calculate ageadjusted mortality rates and rate ratios rrs. Disseminated blastomycosis definition of disseminated.

Also find information on surveillance and guidance for health professionals. Dogs that are frequently exposed to environments where blastomyces dermatitidis exists are at. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. The signs and symptoms of blastomycosis vary and may occur from 3 to 15 weeks after inhaling the fungus. Symptoms of blastomycosis usually appear between 3 weeks and 3 months after a person breathes in the fungal spores. Blastomycosis is a systemic infection caused by the thermally dimorphic fungus blastomyces dermatitidis that can result in severe disease and death among humans and animals. Pneumonia why is it a concern in northwestern ontario. Treatment and outcomes of blastomycosis blastomycosis. The fungus can then spread to other parts of the body. People have a fever, chills, and drenching sweats and sometimes. We modeled trends over time using poisson regression.

In states where blastomycosis is reportable, yearly incidence rates are approximately 1 to 2 cases per 100,000 population. Blastomycosis is an infection caused by various related genotypes of the fungus blastomyces dermatitidis. Blastomycosis is a rare fungal infection that commonly involves the lungs and skin. Epidemiology, diagnosis, and treatment of blastomycosis in. The berkeley lazy abstraction software verification tool blast is a software model checking tool for c programs. This fungal disease lecture explains the blastomycosis, fungal infection. Model checker for solver checks solver errors and warnings.

The fungus grows in thickly wooded areas and along streams and rivers, where there is. Given a c program and a temporal safety property, blast either statically proves that the program satisfies the safety property, or provides an execution path that exhibits a violation of the property or, since the problem is undecidable, does not terminate. Find out what the risks are and who is most at risk. Death occurred more often among older persons rr 2. Our experiments show that blast can provide automated, precise, and scalable analysis for. Additional and relevant useful information for blastomycosis. Amphotericin b is usually recommended for severe blastomycosis in the lungs or infections that have spread to other parts of the body. If it involves only the lungs, it is called pulmonary blastomycosis. Blastomycosis is an infection caused by a fungus called blastomyces. Blastomycosis is a systematic yeastlike fungal infection caused by the organism blastomyces dermatitidis, which is commonly found in decaying wood and soil. Blastomycosis definition of blastomycosis by the free. Clinical and laboratory update on blastomycosis ncbi. Blastomycosis definition is any of several fungal infections. The clinical manifestations of blastomycosis are varied and include asymptomatic infection, acute or chronic pneumonia, and extrapulmonary disease 1.

Itraconazole is a type of antifungal medication that is typically used to treat mild to moderate blastomycosis. You can get blastomycosis by contact with moist soil, most commonly where there is rotting wood and leaves. Unlike most fungal infections, blastomycosis is not more common among people with aids. Blastomycosis is also termed north american blastomycosis, gilchrists disease, and blastomycetic dermatitis. Clinical practice guidelines for the management of blastomycosis. Sources of blastomycosis blastomycosis fungal disease. The signs and symptoms of illness that can result from exposure to this soil organism are variable. When people or animals breathe in the spores, they are at risk for developing blastomycosis. The software model checker blast software and computational. Over half of affected persons exhibit minimal symptoms, but in acute cases, 2040% of patients see involvement of. These symptoms usually develop between three weeks and three months after. Blastomycosis, infection of the skin and viscera caused by fungal organisms of the genus blastomyces. Learn about blastomycosis, its causes, symptoms, risks, treatment and prevention. It explains the symptoms, pathology, identification and treatment of blastomycosis.

It is hoped that its recognition as a diagnostic possibility by the laryngeal textbooks of the future will lead not only to its more frequent detection, but to the early diagnosis that may result in cure of the otherwise fatal disease. Blastomycosis is a fungal infection caused by inhaling blastomyces dermatitidis spores. However, it tends to be more severe in people with aids. Blastomycosis occurs most frequently in male dogs, but female dogs are also susceptible. Blastomyces helicus, which has been moved into the genus blastomyces, has been identified as a cause of disease in a very small. Blastomycosis refers to disease caused by the dimorphic fungus. Blastomycosis wisconsin department of health services. Blastomycosis symptoms, diagnosis, treatments and causes. The natural habitat of this fungus is unclear but it is suspected to come from the soil. An infection caused by the fungus blastomyces dermatitidis and characterized by multiple inflammatory lesions of.

It is endemic in the central and southeastern united states including the ohio and mississippi river valleys, in the great lakes region, and in parts of canada ontario, manitoba, southern saskatchewan. The disease may affect the skin, bones and joints, and other areas. In the united states, blastomyces mainly lives in the midwestern, southcentral, and southeastern states, particularly in areas surrounding the ohio and. You can now do a quick check of your finite element model using the new model checking with auto correction feature. Ecologic niche modeling of blastomyces dermatitidis in wisconsin. Clinical presentations occur across a wide spectrum, ranging from an asymptomatic, selflimited pulmonary infection to widely disseminated lifethreatening disease. Skin lesions in blastomycosis may look like a wart or an ulcer.

Blastomycosis may be more common among and more severe in some people with a weakened immune system. Although blastomycosis has been reported to involve almost every organ, the lungs are the most common site of infection, followed by the skin, bones, and genitourinary system. Symptoms can range from flu and pneumonialike to chronic appearances which resemble tuberculosis, lung cancer, and acute respiratory distress syndrome. Model checking with auto correction feature altair. Symptoms result from pneumonia or from dissemination to multiple organs, most commonly the skin. Blastomycosis of the larynx is a rare disease, though probably not as rare as the paucity of literature on the subject would indicate.

Software model checking zprogram behaviorprogram behavior zpredicate abstraction zcounterexampleguided abstraction refinement part ii. The spores are too small to see without a microscope. Moved by gardening, camping, hunting, hiking, riding allterrain vehicles, or clearing brush. Infection is characterized by pyogranulomatous lesions in various tissues, frequently the lungs or skin.

Symptoms of blastomycosis blastomycosis fungal disease. Cases in which acute pneumonia resolves spontaneously are documented 64, 103, 109. However, high band neutrophil counts have been correlated with decreased survivability in canine patients with pulmonary blastomycosis. It may take 21 to 45 days or more before you develop symptoms. Blastomycosis is an infection caused by a fungus, blastomyces dermatiditis. Blastomyces mainly lives in areas of the united states and canada surrounding the ohio and mississippi river valleys and the great lakes. N2 blastomycosis is one of the most common systemic fungal diseases in dogs in north america, but it is rarely diagnosed in cats. Blastomycosis infections merck manuals consumer version. Model checker for element checks quality of the elements. Modelchecking techniques and tools, isbn 3540415238. Sources of blastomycosis blastomycosis fungal disease cdc. The disease does not spread from one person to another.

Blastomyces lives in the environment and is a fungis that produces fungal spores. It traces its roots to logic and theorem proving, both to. Blastomycosis is a systemic pyogranulomatous infection caused by the inhalation of conidia spores of b dermatitidis, the asexual imperfect form of ajellomyces dermatitidis, a dimorphic fungus. The laboratory diagnosis of blasto mycosis is established by using a va riety of tests. Blastomycosis is an uncommon, but potentially serious fungal infection. Blastomycosis does occur outside the endemic zones, but with much less frequency. It primarily affects the lungs, and is caused by the fungus blastomyces dermatitidis. Models were generated with humanonly cases, canineonly cases, random and checkerboardstratified subsets of occurrences and northern or. Blastomycosis is infection, mainly of the lungs, caused by the fungus blastomyces dermatitidis. Blastomycosis has also been reported in mexico, the middle east, africa, india, and south and central america.

Blastomycosis is a systemic pyogranulomatous infection, primarily involving the lungs, which arises after inhalation of the conidia of blastomyces dermatitidis. Blastomycosis is not known to spread from person to person. The fungus is often found in soil or decomposing organic matter, such as leaves. Kauffman1 1division of infectious diseases, university of michigan medical school, veterans affairs ann arbor healthcare system, ann arbor, michigan blastomycosis is an endemic mycosis that occurs predominantly in north america in the north central united states and provinces of. Blastomycosis is a fungal infection caused by inhalation of aerosolized conidia spores of blastomyces dermatitidis. In approximately 25% of blastomycosis cases, only the lungs are. Blastomycosis is an uncommon infection of humans, dogs, cats and other animals caused by the fungus blastomyces dermatitidisfound in soil.

When people or animals breathe in the spores, they are at risk for developing. Visit our research pages for current research about blastomycosis treatments clinical trials for blastomycosis. The fungus lives in the environment, particularly in moist soil and in decomposing organic matter such as wood and leaves. About blastomycosis blastomycosis fungal disease cdc. Model checking deutsch auch modellprufung ist ein verfahren zur vollautomatischen. The fungus enters the body through the lungs, where the infection starts. The clinical manifestations of blastomycosis are varied and include asymptomatic infection, acute or chronic pneumonia, and extrapulmonary disease. Blastomycosis is a multifocal fungal infection caused by the dimorphic fungus blastomyces dermatitidis. You can get blastomycosis when you breathe in air around dirt that has been disturbed. Blastomycosis statistics blastomycosis fungal disease. The infection affects the lungs and skin sometimes resulting in pneumonia or crusted, ulcerated pimples. Only about half of people with the disease have symptoms, which can include fever, cough, night sweats, muscle pains, weight loss, chest pain, and feeling tired.

Since louisiana appears to have a potential highrisk area and because of a lack of sufficient data, blastomycosis was added to the list of reportable diseases as of september 1988. Symptoms can range from a mild cough that does not go away to serious breathing problems. Blastomycosis is a reportable condition in louisiana because of concerns about the focus in southeast louisiana. In the early stages, symptoms may include a dry cough, fever, heavy sweating, fatigue, and a general feeling of ill health. Learn about the symptoms, what to look for and what to do if you become ill. Blastomycosis definition of blastomycosis by merriamwebster. For simple nondeterministic system, use spin, nusmv or nuxmv model checkers. T1 epidemiology, diagnosis, and treatment of blastomycosis in dogs and cats. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Finally, selected reports dealing with the in vitro susceptibility of b. Approximately 50% of people who are infected with b. After the spores enter the lungs, the body temperature allows the spores to transform into yeast.